Safe (1995) - Julianne Moore, Xander Berkeley, Dean Norris, Julie Burgess, Peter Friedman

In a standout performance, Julianne Moore plays Carol White, a Los Angeles housewife in the late 1980s who comes down with a debilitating illness. When doctors give her no clear diagnosis, she comes to believe that she has frighteningly extreme environmental allergies. A profoundly unsettling work from director Todd Haynes, Safe functions on multiple levels: as a prescient commentary on self-help culture, as a metaphor for the AIDS crisis, as a drama about class and social estrangement, and as a horror film about what you cannot see.