The film opens as the klutzy Valerie Highsmith (Sheila Kelley) arrives at an airport in Puerto Vallarta. She calls her father (Wanamaker), a wealthy businessman, to let him know that she has arrived. While she is on the phone, she clumsily leans on the railing of her balcony and falls several stories onto a canvas. Soon after, an encounter with some street thieves knocks her unconscious and she loses her memory, then a local criminal named Frank Grimes (Scott Wilson) spirits Valerie away from her hotel.
A psychologist named Monosoff (Harry Shearer), knowing that Valerie has ultra bad luck, persuades her father to send one of his employees, Eugene Proctor (Martin Short), an accountant with super bad luck, to find her. Perhaps he will be lucky, and his bad luck could help to find the unlucky girl. Eugene is partnered with Raymond Campanella (Danny Glover), a hardnosed investigator, who bristles at Eugene's every move.
As they travel to Mexico together, they endure one mishap after another, from damaged luggage and bad hotel rooms to bar fights with strangers. Eventually, they are told by the local police that Valerie was last seen with Frank Grimes. Eugene thinks that he can press a local prostitute for information, but she robs him. Raymond tracks the prostitute down at a gambling club (run by a man named Fernando) and confronts several men at gunpoint to retrieve Eugene's money. Neither of them realizes that Frank Grimes is seated at the table, until after they drive away and look at his picture one more time.....
Directed by Nadia Tass
Produced by Sean Daniel
Conrad Hool
Lance Hool
Francis Veber
Written by Francis Veber
Herschel Weingrod
Timothy Harris
Starring
Martin Short
Danny Glover
Sheila Kelly
Scott Wilson
Sam Wanamaker
Music by
Jonathan Sheffer
Danny Elfman (main titles)
Cinematography David Parker
Edited by Billy Weber