Risks & Negative Effects.
Extreme fear and terror can occur.
Delayed effects such as muscle tension, difficulty sleeping, and flashbacks to the initial drug session may be experienced up to 1 week after 5-MeO-DMT use.
Very few cases report hallucinogen-persisting perception disorder (HPPD) in which psychological symptoms or flashbacks persist weeks to years after psychedelic use. But there hasn't been investigations or organized efforts to collect information about negative outcomes.
List of common negative effects:
Neusea or vomiting, confusion, delusion, loss of motor control, anger, sadness or anger, tremors, shaking, pupil dilation, blackout, skin flushing etc.
Risk of Serotonin Toxicity
Drugs that increase the amount of serotonin in synapses can potentially cause serious adverse events if serotonin levels reach a toxic threshold. Medications classified as monamine oxidase inhibitors (MAOIs), serotonin re-uptake inhibitors (SRIs, SSRIs, SNRIs), and serotonin releasing agents (MDMA) are associated with serotonin toxicity. Combination of these drugs can escalate risk for having too much serotonin accumulate in neural synapses.
5-MeO-DMT should NOT be taken with monamine oxidase inhibitors (MAOIs)! As we learned earlier, metabolism of 5-MeO-DMT relies on MAO.
If 5-MeO-DMT is taken alone within defined dose ranges, the risk for serotonin toxicity is reportedly low. More research is needed to understand how other sertonergic drugs, including SSRIs, possibly interact with 5-MeO-DMT to affect toxicity.
Lithium should be avoided with 5-MeO-DMT because of increased chance of seizures.
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