Dosing, Duration of Effects, & Routes of Administration
Smoking 5-MeO-DMT or vaporization results in a rapid onset of effects after about 10 seconds. Peak effects occur in roughly 2-10 minutes, lasting for 15-30 minutes
Intranasal administration and intramuscular injection of 5-MeO-DMT produce a slower onset of effects (intranasal: 5-7 mins, intramuscular: 1-6 mins), peak at 10-30 mins, and have longer-lasting effects up to 1 hour.
Intravenous injection allows for complete bioavailability and precise control of dosage, but the onset of effects is very rapid and individuals can be sensitive to even small changes in dose.
Buccal/Sublingual administration also avoids first pass metabolism but absorption may be limited or too slow.
5-MeO-DMT is an extremely potent substance. In fact, most users report the 5-MeO-DMT experience to be distinct from and much more intense than other psychedelics (Barsuglia, 2018; Davis, 2018).
Depending on the route of administration, the onset and duration of effects vary. Synthetic 5-MeO-DMT and toad forms differ in terms of dosing and route of administration. Toad venom can only be administered through vaporization because of other chemicals present in the venom.
Because individuals can experience a range of intensity at any given dose, facilitators will often first administer a very low dose to test a person's sensitivity to the substance. The lower dose ranges allow the user to become familiar with nature of the effects. If well tolerated, the dose can be increased to achieve broader shifts in consciousness.
Smoked Dosage.
Threshold: 1 mg.
Light: 3 - 6 mg.
Common: 6 - 12 mg.
Strong: 12 - 20 mg.
Heavy: 20 mg +
Duration.
Total: 20 - 40 minutes
Onset: 5 - 60 seconds
Come up: 30 - 60 seconds
Peak: 5 - 15 minutes
Offset: 10 - 20 minutes
After effects_ 15 - 60 minutes
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