Puli Pharmaceutical possesses liquid hard capsule filling technology and self emulsifying microemulsion technology. We sincerely invite joint research on five hundred and five (b) (two) innovative drugs!

Puli Pharmaceutical possesses liquid hard capsule filling technology and self emulsifying microemulsion technology. We sincerely invite joint research on five hundred and five (two) innovative drugs! Puli Pharmaceutical has mature liquid hard capsule filling technology; Self emulsifying microemulsion technology invites joint research on five hundred and five (two) innovative drugs! Recently, many companies have consulted our company about liquid hard capsule filling technology. It is also common for many pharmaceutical companies to seek CDMO/CMO services related to liquid hard capsule filling on various communication platforms. Puli Pharmaceutical has complete liquid hard capsule filling technology and self emulsifying microemulsion technology. We sincerely invite major pharmaceutical companies to cooperate and use hard capsule filling technology combined with self emulsifying microemulsion technology to solve the absorption problem of insoluble drugs, and work together to create five hundred and five (two) innovative drugs! one Liquid Hard Capsule Filling Technology Capsules, currently one of the most widely used dosage forms in oral solid preparations, can be divided into hard capsules and soft capsules. Soft capsules often experience stability issues such as adhesion, leakage, and delayed disintegration during their shelf life, which affects their quality and safety. Hard capsule refers to a capsule formulation that uses appropriate formulation techniques to fill the hollow capsule with a uniform powder, particle, small piece, pellet, semi-solid or liquid supported by raw materials or appropriate excipients. The biggest advantage of delivering liquid drugs through hard capsules is that it can solidify the liquid drugs, reduce drug storage and transportation costs. At the same time, most of the filled liquids contain water-insoluble drugs, and drugs exist in the form of emulsions/microemulsions and suspensions. Compared with tablets and microspheres, it can significantly increase the solubility of drugs. Moreover, such products do not require disintegration and disintegration processes after entering the gastrointestinal tract, and can be directly absorbed through the gastrointestinal tract, thereby improving the bioavailability of drugs. In foreign markets, multiple liquid hard capsule filling products have been launched, such as the Co danthromer developed by NAPP for the treatment of constipation. Each capsule is filled with fiveml of liquid, containing twenty-fivemg of dihydroxyanthraquinone and two hundredmg of poloxamer one hundred and eighty-eight. Dihydroxyanthraquinone can stimulate the nerve endings of the intestinal wall, making muscle contractions more frequent and powerful. poloxamer one hundred and eighty-eight is a fecal softener, and the two substances work together to alleviate constipation problems in patients. In addition to Co danthromer, globally available liquid filled hard capsule products also include Sankyo's Captopril-R, TEVA's Claravis, and Mylan's Mevalonate. Beverine and GSK's Combodart, among others. In the domestic market, as one of the few pharmaceutical companies that has mastered the technology of liquid hard capsule filling, Puli looks forward to working together with other enterprises to explore the infinite possibilities of hard capsule filling technology. two Self Emulsifying Microemulsion Technology Self Emulsifying Drug Delivery System (SEDDS) is a water in oil (O/W) emulsion formed by spontaneous emulsification of lipophilic or hydrophobic drugs, oil phase, surfactants, and co surfactants under the internal environmental conditions of gastrointestinal peristalsis, with a particle size of less than five hundrednm. SEDD