Kate and Meg are childhood friends and roommates in Seattle experiencing stressful times. Kate is a high school English teacher who is being pressured by Principal Moss to resign, while Meg is a struggling cosmetics saleswoman. After a night of drinking, Meg suggests they go on vacation together to escape their stressful lives. Kate is reluctant, but ultimately acquiesces as Meg had already booked non-refundable tickets to Fort Lauderdale using Kate's frequent flyer miles.
On the plane, Kate and Meg are seated next to Ryan, a handsome firefighter on his way to a wedding. Both women are immediately attracted to him and begin to shamelessly flirt with him. A few hours into the flight, the plane is diverted to St. Louis due to a hurricane warning. The women are taken to the local Sheraton and run into Ryan, who invites them to drinks at the hotel club. Before going to bed, Kate tells Meg that she will fight her for Ryan's affections.